RayBiotech,Inc.

Product Focus: Adipokines & Obesity related products

Introduction

Obesity Frontier

Adipokine Related Products Overview

Adipokine Antibody Arrays: sandwich-based

L Series Adipokine Arrays: Label based

Quantibody Adipokine Arrays: Quantitative

ELISA Kits

Antibody

Enzyme Immunoassay (EIA) Based Kits

Peptide

Protein

Introduction

Adipose tissue is no longer viewed as an inert energy storage organ, but is emerging as an active participant in regulating physiological and pathologic processes. Many soluble factors have been identified from the adipose tissue and are so called as adipocytokines or adipokines. Some of the adipokines are mainly produced by the adipose tisse like leptin and resistin, while others are also synthesized in other tissues like TNF-alpha, IL-6, MCP-1, and IL-1. Because all of these factors can act in an autocrine , paracrine or endocrine manner in the organisms, adipokines are thought to serve as mediators linking obesity, metabolic syndrome, diabetes, inflammation, immunity and other obesity-related diseases.

	Adipokine Antibody Arrays: sandwich-based (Cat# AAH-ADI-1 or AAH-ADI-G1)
As the protein array pioneer company, RayBiotech provides the most comprehensive cytokine antibody array products in today's market. Using our patent pending technology, researchers can rapidly and accurately measure the expression levels of 62 different adipokines from a single sample semi-quantitatively. The technology is designed based on the sandwich immunoassay principle. A panel of antibodies is immobilized in specific spot locations on the surface of membrane or a glass chip. Incubation of array membranes with biological samples results in the capture of adipokines by corresponding antibodies. The bound proteins are then detected with a cocktail of biotinylated antibodies. Finally, signals are visualized using chemiluminescence, colorimetry or fluorescence.


	High Sensitivity: detects most proteins at pg levels
	Affordable enough for routine use
	High specificity
	May be used with diverse biological samples
	Customizable
	Requires as little as 100 ul (membranes) or 30 ul (glass chip)
	Click for further information on all antibody array products.

Antibody List:

4-1BB	IGFPB-2	Leptin	PDGF-BB
ACE-2	IGFPB-3	Leptin R	RANTES
Acrp30	IGF-I	LIF	Resistin
Adipsin	IGF-1 sR	Lymphotactin	Serum Amyloid A
AgRP	IL-1 R4/ST2	MCP-1	SDF-1
Ang-2	IL-1 sRI	MCP-3	sTNF RII
Angiopoietin-1	IL-10	MCSF	sTNT RI
ANGPTL4	IL-11	MIF	TECK
CRP	IL-12	MIP-1beta	TGF-beta
ENA-78	IL-1 alpha	MSP a-chain	TIMP-1
Fas	IL-1 beta	OPG	TIMP-2
FGF-6	IL-6	OSM	TNF-alpha
Growth Hormone	IL-6 sR	PAI-I	VEGF
HCC-4	IL-8	PARC	XEDAR
IFN-gamma	Insulin	PDGF-AA
IGFBP-1	IP-10	PDGF-AB

L-Series Adipokine Arrays: Label-based

Recent technological advances by RayBiotech have enabled the largest commercially available antibody array to date. With the L Series Antibody Array, researchers can now obtain a broad, panoramic view of cytokine expression. The expression levels of 182 human adipokines can be simultaneously detected in cell culture supernates or serum. Furthermore, an internal control is used to monitor the whole process including biotin-labeling, so this high density array will accurately reflect available adipokines in your sample.

* Click for further information on all Label-Based antibody array products.

Antibody List:
	Target Protein		Target Protein		Target Protein
1	ACE / CD43	62	Ghrelin	123	Neurophilin-2
2	ACE-2	63	GITR	124	NGF R
3	ACTH	64	GITRL	125	NPY (Neuropeptide Y)
4	ADFP	65	GLP-1	126	Obestatin R (GPR-39)
5	Adiponectin / Acrp30	66	Glucagon	127	Orexin A
6	Adipsin (Factor D)	67	Glut1	128	Orexin B
7	AgRP	68	Glut2	129	OSM
8	AMPKa1	69	Glut3	130	Osteocalcin
9	Amylin	70	Glut5	131	Osteonectin
10	Angiopoietin-1	71	Glutathione peroxidase 1	132	Osteoprotegerin
11	Angiopoietin-2	72	Glutathione peroxidase 3	133	PARC
12	Angiotensinogen / Angiotensin II	73	GROa	134	PDGF
13	Ang-like Factor	74	HCC4	135	PDGF-AA
14	ANGPTL1	75	HGF	136	PDGF-AB
15	ANGPTL2	76	HSD-1	137	PDGF-C
16	ANGPTL3	77	ICAM1	138	PDGF-D
17	ANGPTL4	78	IFNg	139	PEDF
18	Apelin Receptor	79	IGF-1	140	Pentraxin-3
19	ApoB	80	IGF-1 sR	141	PPARg2 / NRIC3
20	ApoE	81	IGFBP-1	142	Pref-1
21	Axl	82	IGFBP-2	143	Prohibitin
22	BDNF	83	IGFBP-3	144	Prolactin
23	bFGF	84	IGF-II	145	PYY
24	BMP-2	85	IL-1 R1	146	RANTES
25	BMP-3	86	IL-1 R4	147	RBP4
26	BMP-3b / GDF-10	87	IL-1a	148	RELMb
27	BMP-4	88	IL-1b	149	Resistin
28	BMP-5	89	IL-1ra	150	S100
29	BMP-6	90	IL-6	151	S100 A8+A9
30	BMP-7	91	IL-6 sR	152	S100 A10
31	BMP-8	92	IL-8	153	SAA
32	BMP-15	93	IL-10	154	SDF-1
33	BMPR-IA / ALK-3	94	IL-11	155	SEMA3A
34	BMPR-IB / ALK-6	95	IL-12	156	Serotonin
35	BMPR-II	96	IL-25 / IL-17E	157	Syndecan-3
36	b-NGF	97	INSL3	158	TACE
37	C3a des Arg	98	INSRR	159	TDAG51
38	CART	99	Insulin	160	TECK
39	CD137 (4-1BB)	100	Insulin R (CD220)	161	TGF-a
40	CD36	101	Leptin	162	TGF-b
41	Clusterin	102	Leptin R	163	Thrombospondin 1
42	CNTF	103	LH (Luteinizing Hormone)	164	Thrombospondin 2
43	C-peptide	104	LIF	165	Thrombospondin 4
44	CRP	105	LOX	166	TIMP-1
45	Cystatin C	106	Lymphotactin	167	TIMP-2
46	Dtk	107	MCP-1	168	TIMP-3
47	EGF	108	MCP-3	169	TIMP-4
48	EGF-R	109	M-CSF	170	Tissue factor (CD142)
49	ENA-78	110	MIF	171	TLR2
50	Endophin Beta	111	MIP-1a	172	TLR4
51	Epiregulin	112	MIP-1b	173	TNF alpha
52	E-selectin	113	MIP-3b	174	TNF sRI
53	ET-1 (Endothelin)	114	MMP-2	175	TNF sRII
54	FABP4	115	MMP-9	176	TSG-6
55	FAM3B	116	MMP-11	177	TSH
56	FAS / Apo-1	117	MMP-19	178	Vaspin
57	FGF-10	118	MSHa	179	VCAM1
58	FGF-6	119	MSPa	180	VEGF
59	FSH	120	Myostatin	181	Visfatin/PBEF1
60	Galectin -1	121	NAIP	182	XEDAR
61	GH (Growth Hormone)	122	NeuroD1