The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of stimuli and controls fundamental cellular processes such as apoptosis, metabolism, proliferation, protein synthesis, growth, and survival. Dysregulation of this pathway is implicated in a number of disease states including cardiovascular and neurological disease, diabetes, and particularly cancer. This has led to the development of a number of small molecule inhibitors of both PI3K and Akt for use in therapeutic treatment of some of these diseases.
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