Formalin-fixed, paraffin-embedded human lung Adenocarcinoma stained with TTF1 antibody (NX2.1/690)

Mouse anti-Human/Mouse/Rat TTF1 Antibody [IHC only]

Mouse anti-Human/Mouse/Rat TTF1 Antibody [IHC only]


Antigen Information

Accession Number:
  • P43699
Gene ID:
  • 7080
Gene Symbols:
  • NKX2-1
  • NKX2A
  • TITF1
  • TTF1
Protein Name & Synonyms:
Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)
Target Species:
  • Human
  • Mouse
  • Rat

Antibody Specifications

Prediluted format : incubate for 30 min at RT (2)
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*
Host Species:
Recombinant protein was used as the immunogen for the TTF1 antibody.
Protein G affinity chromatography
Species Reactivity:
Human, Mouse, and Rat. Other species not tested.
Mouse IgG1, kappa


Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.


The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

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This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.