Mouse anti-Human TFF1 Antibody

Mouse anti-Human TFF1 Antibody

$198.00
188-11407-1
+

Antigen Information

Accession Number:
  • P04155
Gene ID:
  • 7031
Gene Symbols:
  • BCEI
  • PS2
  • TFF1
Protein Name & Synonyms:
Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)
Target Species:
  • Human

Antibody Specifications

Applications:
Immunofluorescence: 0.5-1ug/ml
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Concentration:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Domain/Region/Terminus:
Cytoplasmic
Host Species:
Mouse
Preparation:
A C-terminus peptide was used as the immunogen for the TFF1 antibody.
Purity:
Protein G affinity chromatography
Species Reactivity:
Human. Other species not tested.

Description

TFF1/Breast cancer estrogen inducible protein pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. TFF1/pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. TFF1 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract.

Storage

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.