Active Caspase-1, Rat recombinant

$386.00  
268-11114-1
+

Product Specifications

Size:
25 units or 100 units
Format:
Semi-Dry

Source

Gene Symbols:
  • CASP1
Species:
Rat
Accession Number:
  • P43527
Protein Name & Synonyms:
Caspase-1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.

Preparation

Expression System:
E.Coli
Molecular Weight (kDa):
~ 34.6 KDa

Introduction

Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques.

Stability & Storage

Shipping
Gel Pack
Storage/Stability
The protein may be stored for 12 months at -80°C

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.