Active SIRT2, Human recombinant

$301.00  
268-11250-1
+

Product Specifications

Size:
10 ug, 50 ug, or 1 mg

Source

Gene Symbols:
  • SIRT2
Species:
Human
Accession Number:
  • Q8IXJ6
Gene ID:
  • 22933
Protein Name & Synonyms:
NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2, SIR2L, SIR2L2.

Preparation

Expression System:
E.Coli
Purity:
&ge,90% determined by SDS-PAGE
Molecular Weight (kDa):
Human SIRT2 is a 60 kDa (2 to 389 aa + NT His Tag) protein

Protein Specifications

Format:
Human Sirtuin 2 is lyophilized from 50 mM Tris, pH 8.0.

Introduction

Sirtuins function as intracellular regulatory proteins. Human Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. Human SIRT2 is a cytoplasmic protein responsible for the deacetylation of histone H4 and a-tubulin, a modification important for controlling the cell cycle. Specifically, SIRT2 protein co-localizes with HDAC6 and microtubules and functions as a mitotic checkpoint in preventing chromosomal instability that can lead to hyperploid cells. SIRT2 is found in many tissues, but is specifically enriched in skeletal muscle, the heart, and in oligodendroglia cells in the brain. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A.

Stability & Storage

Shipping
gel pack
Storage/Stability
The protein may be stored for 12 months at -20°C

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.