The discovery of the iron oxide magnetic nanoparticle (IONP) has had profound effects in the field of nanobiotechnology. It was the first nanoparticle to be approved for human use as MRI contract agent. Recently, developments in preparation and surface modification chemistry of IONPs have led to well-controlled size and super colloidal stability of IONPs and opened a door for their widespread application in nanobiotechnology. The IONPs we have develop with unique surface modification chemistry can load a large amount of organic dye molecules on their surface and form much brighter, dye labelled magnetic particles (MagDye). MagDye also provides reaction groups such as carboxyl or amine for further conjugation with biomolecules. Attributed to its small size and high brightness, MagDye makes it possible to measure individual virus and/or exosomes by a flow cytometer. Furthermore, since MagDye is magnetic and can be separated by a magnet, removing the unreacted biomolecules after conjugation becomes a much easier task. This may lead to the ability to magnetically separate cells or concentrate proteins for further analysis. 9MDA-05 are amine functionalized MagDye with emission wavelength of 665 nm.
Cyanine5 (Cy5) conjugated
Functional Group Density
DI water, 0.02% NaN3
2-8 °C; Do not freeze. Keep vial upright.