Angiogenesis Arrays

RayBiotech offers 12 different Angiogenesis Antibody Arrays for detecting up to 60 angiogenic proteins / biomarkers in human and mouse species. See the below product listings for more information.

Human Angiogenesis Arrays

Human Angiogenesis Array Q1

Human Angiogenesis Array Q1

(QAH-ANG-1)

Quantibody Arrays - Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 10 Human Cytokines:

Angiogenin, Angiopoietin-2, EGF, bFGF, HB-EGF, HGF, Leptin, PDGF-BB, PLGF, VEGF-A

PDFManualOverviewQuantibody Overview

Human Angiogenesis Array Q2

Human Angiogenesis Array Q2

(QAH-ANG-2)

Quantibody Arrays - Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 30 Human Cytokines:

Activin A, AgRP, Angiogenin, Angiopoietin-2, ANGPTL4, bFGF, ENA-78 (CXCL5), GRO alpha/beta/gamma, HB-EGF, HGF, IFN-gamma, IGF-1, IL-1 alpha (IL-1 F1), IL-2, IL-6, IL-8 (CXCL8), IL-17A, IP-10 (CXCL10), Leptin, LIF, MCP-1 (CCL2), PDGF-BB, PLGF, RANTES (CCL5), TGF beta 1, TIMP-1, TIMP-2, TNF alpha, TNF beta (TNFSF1B), Thrombopoietin (TPO)

PDFManualOverviewQuantibody Overview

Human Angiogenesis Array Q3

Human Angiogenesis Array Q3

(QAH-ANG-3)

Quantibody Arrays - Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 30 Human Cytokines:

Angiogenin, Angiostatin, CXCL16, EGF, FGF-4, Follistatin, GCSF, GM-CSF, I-309 (TCA-3/CCL1), IL-1 beta (IL-1 F2), IL-4, IL-10, IL-12 p40, IL-12 p70, I-TAC (CXCL11), MCP-2 (CCL8), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PECAM-1 (CD31), TGF alpha, TGF beta 3, Tie-1, Tie-2, uPAR, VEGF-A, VEGFR2, VEGFR3, VEGF-D

PDFManualOverviewQuantibody Overview

Human Angiogenesis Array Q1000

Human Angiogenesis Array Q1000

(QAH-ANG-1000)

Quantibody Arrays - Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 60 Human Cytokines:

Activin A, AgRP, Angiopoietin-1, Angiopoietin-2, Angiogenin, Angiostatin, ANGPTL4, bFGF, CXCL16, EGF, ENA-78 (CXCL5), FGF-4, Follistatin, GCSF, GM-CSF, GRO alpha/beta/gamma, HB-EGF, HGF, I-309 (TCA-3/CCL1), IFN-gamma, IGF-1, IL-10, IL-12 p40, IL-12 p70, IL-17A, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, IL-6, IL-8 (CXCL8), IP-10 (CXCL10), I-TAC (CXCL11), Leptin, LIF, MCP-1 (CCL2), MCP-2 (CCL8), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PDGF-BB, PECAM-1 (CD31), PLGF, RANTES (CCL5), TGF alpha, TGF beta 1, TGF beta 3, Tie-1, Tie-2, TIMP-1, TIMP-2, TNF alpha, TNF beta (TNFSF1B), Thrombopoietin (TPO), uPAR, VEGF-A, VEGFR2, VEGFR3, VEGF-D

PDFManualOverviewQuantibody Overview

Human Angiogenesis Array C1

Human Angiogenesis Array C1

(AAH-ANG-1)

C-Series Arrays - Semi-Quantitative, Sandwich-Based, Membrane Antibody Arrays

Detects 20 Human Cytokines:

Angiogenin, EGF, ENA-78 (CXCL5), bFGF, GRO alpha/beta/gamma, IFN-gamma, IGF-1, IL-6, IL-8 (CXCL8), Leptin, MCP-1 (CCL2), PDGF-BB, PLGF, RANTES (CCL5), TGF beta 1, TIMP-1, TIMP-2, Thrombopoietin (TPO), VEGF-A, VEGF-D

PDFManualOverviewC-Series Overview

Human Angiogenesis Array C2

Human Angiogenesis Array C2

(AAH-ANG-2)

C-Series Arrays - Semi-Quantitative, Sandwich-Based, Membrane Antibody Arrays

Detects 23 Human Cytokines:

Angiopoietin-1, Angiopoietin-2, Angiostatin, Endostatin, GCSF, GM-CSF, I-309 (TCA-3/CCL1), IL-10, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, I-TAC (CXCL11), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PECAM-1 (CD31), Tie-2, TNF alpha, uPAR, VEGFR2, VEGFR3

PDFManualOverviewC-Series Overview

Human Angiogenesis Array C1000

Human Angiogenesis Array C1000

(AAH-ANG-1000)

C-Series Arrays - Semi-Quantitative, Sandwich-Based, Membrane Antibody Arrays

Detects 43 Human Cytokines:

Angiogenin, Angiopoietin-1, Angiopoietin-2, Angiostatin, bFGF, EGF, ENA-78 (CXCL5), Endostatin, GCSF, GM-CSF, GRO alpha/beta/gamma, I-309 (TCA-3/CCL1), IFN-gamma, IGF-1, IL-10, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, IL-6, IL-8 (CXCL8), I-TAC (CXCL11), Leptin, MCP-1 (CCL2), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PDGF-BB, PECAM-1 (CD31), PLGF, RANTES (CCL5), TGF beta 1, Thrombopoietin (TPO), Tie-2, TIMP-1, TIMP-2, TNF alpha, uPAR, VEGF-A, VEGFR2, VEGFR3, VEGF-D

PDFManualOverviewC-Series Overview

Human Angiogenesis Array G1

Human Angiogenesis Array G1

(AAH-ANG-G1)

G-Series Arrays - Semi-Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 20 Human Cytokines:

Angiogenin, EGF, ENA-78 (CXCL5), bFGF, GRO alpha/beta/gamma, IFN-gamma, IGF-1, IL-6, IL-8 (CXCL8), Leptin, MCP-1 (CCL2), PDGF-BB, PLGF, RANTES (CCL5), TGF beta 1, TIMP-1, TIMP-2, Thrombopoietin (TPO), VEGF-A, VEGF-D

PDFManualOverviewG-Series Overview

Human Angiogenesis Array G2

Human Angiogenesis Array G2

(AAH-ANG-G2)

G-Series Arrays - Semi-Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 23 Human Cytokines:

Angiopoietin-1, Angiopoietin-2, Angiostatin, Endostatin, GCSF, GM-CSF, I-309 (TCA-3/CCL1), IL-10, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, I-TAC (CXCL11), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PECAM-1 (CD31), Tie-2, TNF alpha, uPAR, VEGFR2, VEGFR3

PDFManualOverviewG-Series Overview

Human Angiogenesis Array G1000

Human Angiogenesis Array G1000

(AAH-ANG-G1000)

G-Series Arrays - Semi-Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 43 Human Cytokines:

Angiogenin, Angiopoietin-1, Angiopoietin-2, Angiostatin, bFGF, EGF, ENA-78 (CXCL5), Endostatin, GCSF, GM-CSF, GRO alpha/beta/gamma, I-309 (TCA-3/CCL1), IFN-gamma, IGF-1, IL-10, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-2, IL-4, IL-6, IL-8 (CXCL8), I-TAC (CXCL11), Leptin, MCP-1 (CCL2), MCP-3 (MARC/CCL7), MCP-4 (CCL13), MMP-1, MMP-9, PDGF-BB, PECAM-1 (CD31), PLGF, RANTES (CCL5), TGF beta 1, Thrombopoietin (TPO), Tie-2, TIMP-1, TIMP-2, TNF alpha, uPAR, VEGF-A, VEGFR2, VEGFR3, VEGF-D

PDFManualOverviewG-Series Overview

Mouse Angiogenesis Array C1

Mouse Angiogenesis Array C1

(AAM-ANG-1)

C-Series Arrays - Semi-Quantitative, Sandwich-Based, Membrane Antibody Arrays

Detects 24 Mouse Cytokines:

Eotaxin-1 (CCL11), Fas Ligand (TNFSF6), bFGF, GCSF, GM-CSF, IFN-gamma, IGF-2, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-12 p40/p70, IL-12 p70, IL-13, IL-6, IL-9, Leptin, MCP-1 (CCL2), M-CSF, MIG (CXCL9), Platelet Factor 4 (CXCL4), TIMP-1, TIMP-2, TNF alpha, Thrombopoietin (TPO), VEGF-A

PDFManualOverviewC-Series Overview

Mouse Angiogenesis Array G1

Mouse Angiogenesis Array G1

(AAM-ANG-G1)

G-Series Arrays - Semi-Quantitative, Sandwich-Based, Glass Slide Antibody Arrays

Detects 24 Mouse Cytokines:

Eotaxin-1 (CCL11), Fas Ligand (TNFSF6), bFGF, GCSF, GM-CSF, IFN-gamma, IGF-2, IL-1 alpha (IL-1 F1), IL-1 beta (IL-1 F2), IL-12 p40/p70, IL-12 p70, IL-13, IL-6, IL-9, Leptin, MCP-1 (CCL2), M-CSF, MIG (CXCL9), Platelet Factor 4 (CXCL4), TIMP-1, TIMP-2, TNF alpha, Thrombopoietin (TPO), VEGF-A

PDFManualOverviewG-Series Overview

Array Features

  • Up to 60 Angiogenesis-related biomarkers are detected simultaneously
  • No need to perform individual immunoprecipitations or Western Blots
  • Reliable results with wide range of cell lines
  • Many compatible sample types, including plasma, serum, cell culture supernatant, lysates, etc.
  • High specificity, sensitivity and reproducibility
  • Membrane formats - No special equipment required
  • Glass slide formats - Fluorescent laser scanner is needed*
  • Many choices: chemiluminescence or fluorescence detection system; Membrane or glass chip

*Click here for a list of compatible laser scanners. Raybiotech now offers free glass slide scanning and data extraction services (click to learn more!).

How It Works

The principle of how an antibody array works

References

  1. Granner T, Maloney S, Antecka E, et al. 3,4 dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells. Br J Ophthalmol. 2013 Mar;97(3):371?374.
    Species: Human
    Sample Type: Conditioned Media
  2. El karim IA, Linden GJ, Irwin CR, Lundy FT. Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts. J Endodontics. 2009;35(6):829?233.
    Species: Human
    Sample Type: Dental pulp fibroblast-Conditioned Media
  3. Differential expression of steroid 5'-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer
    Species: Human
    Sample Type: Cell lysate
  4. Carbamylated low-density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells
    Species: Human
    Sample Type: Serum
  5. Koob T., Lim J., Massee M., Zabek N., Rennet R., Gurtner G., Li W. Angiogenic properties of dehydrated human amnion/chorion allografts. Vascular Cell 2014,6:10 doi:10.1186/2045-824X-6-10 [Epub Ahead of Print] therapeutic potential for soft tissue repair and regeneration
    Species: Human
    Sample Type: Human Microvascular Endothelial Cells Culture Supernatant
  6. Piwnica D, Touraine P, Struman I, Tabruyn S, et al. Cathepsin D Processes Human Prolactin into Multiple 16K-Like N-Terminal Fragments: Study of their Antiangiogenic Properties and Physiological Relevance. Mol Endocrinol. 2004; 18(10):2522-2542.
    Species: African Green Monkey
    Sample Type: Conditioned Media
  7. Tang Y, Nakada MT, Kesevan P, McCabe F, et al. Extracellular Matrix Metalloproteinase Inducer Stimulates Tumor Angiogenesis by Elevating Vascular Endothelial Cell Growth Factor and Matrix Metalloproteinases. Cancer Res. 2005;65(8):3193-3199.
    Species: Human
    Sample Type: Conditioned Media
  8. Tang Y, Nakada MT, Kesevan P, McCabe F, et al. Extracellular Matrix Metalloproteinase Inducer Stimulates Tumor Angiogenesis by Elevating Vascular Endothelial Cell Growth Factor and Matrix Metalloproteinases. Cancer Res. 2005;65(8):3193-3199.
    Species: Human
    Sample Type: Conditioned Media
  9. Goldstein LJ, Chen H, Bauer RJ, Bauer SM, Velazquez OC. Normal human fibroblasts enable melanoma cells to induce angiogenesis in type I collagen. Surgery. 2005; 138:439-449.
    Species: Human
    Sample Type: Conditioned Media
  10. Wang D, Wang H, Brown J, Daikoku T, Ning W,et al.CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med. 2006; 203:941-951
    Species: Human
    Sample Type: Conditioned Media
  11. Fosbrink M, Niculescu F, Rus V, Shin ML, Rus H. C5b-9-induced Endothelial Cell Proliferation and Migration Are Dependent on Akt Inactivation of Forkhead Transcription Factor FOXO1. J Biol Chem. 2006; 281(28):19009-19018.
    Species: Human
    Sample Type: Conditioned Media
  12. McLachlan E, Shao Q, Wang H, Langlois S, Laird DW. Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis. Cancer Res. 2006; 66(20):9886-9894.
    Species: Human
    Sample Type: Conditioned Media
  13. Sze S, Kleijn D, Lai R, Tan E, Zhao H,et al.Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells.Mol Cell Proteomics. 2007; 6: 1680-1692
    Species: Human
    Sample Type: Conditioned Media
  14. Ebihara N, Yamagami S, Yokoo S, Amano S, Murakami A. Involvement of C-C Chemokine Ligand 2-CCR2 Interaction in Monocyte-Lineage Cell Recruitment of Normal Human Corneal Stroma. J Immunol. 2007;178:3288-3292.
    Species: Human
    Sample Type: Conditioned Media
  15. Giorgini s, Trisciuoglio D, Gabellini C, Desideri M, et al. Modulation of bcl-xL in Tumor Cells Regulates Angiogenesis through CXCL8 Expression. Mol Cancer Res. 2007; 5(8):761-767.
    Species: Human
    Sample Type: Conditioned Media
  16. Simcock DE, Kanabar V, Clarke GW, O'Connor BJ, Lee TH, and Hirst SJ. Proangiogenic Activity in Bronchoalveolar Lavage from Patients with Asthma. Am J Respir Crit Care Med 2007; 176(2): 146-153.
    Species: Human
    Sample Type: BAL Fluid
  17. Raghu H., Lakka S., Gondi C., Mohanam S., et al. Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines. PLOS One, Published: August 27, 2010. DOI: 10.1371/journal.pone.0012458
    Species: Human
    Sample Type: Conditioned Media
  18. Gorantla B., Asuthkar S., Rao J., Patel J., et al. Suppression of the uPAR?uPA System Retards Angiogenesis, Invasion, and In Vivo Tumor Development in Pancreatic Cancer Cells. Molecular Cancer Research. April 2011 9; 377
    Species: Human
    Sample Type: Conditioned Media
  19. Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression
    Species: Human
    Sample Type: Conditioned Media
  20. Santo S., Seiler S., Fuchs A. ,Staudigl J., Widmer H. The Secretome of Endothelial Progenitor Cells Promotes Brain Endothelial Cell Activity through PI3-Kinase and MAP-Kinase. PLOSOne, Published: April 22, 2014, DOI: 10.1371/journal.pone.0095731 [Epub ahead of Print]
    Species: Rat
    Sample Type: Endothelial Progenitor Cells, Conditioned Media
  21. Ash S., et al. Xenon decreases cell migration and secretion of a pro-angiogenesis factor in breast adenocarcinoma cells: comparison with sevoflurane. Br. J. Anaesth. (2014) doi: 10.1093/bja/aeu191
    Species: Human
    Sample Type: Conditioned Media
  22. Nedeau A, Bauer R, Gallagher K, Chen H, Liu Z, et al. A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2008;314:2176?2186.
    Species: Human
    Sample Type: Conditioned Media
  23. Luke?ov? S, Kopeck? O, Vroblov? V, Hl?vkov? D, Andr?s C. Determination of Angiogenic Factors in Serum by Protein Array in Patients with Renal Cell Carcinoma. Folia Biologica (Praha). 2008;54:134?140.
    Species: Human
    Sample Type: Serum
  24. Raghu H., Lakka S., Gondi C., Mohanam S., et al. Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines. PLOS One, Published: August 27, 2010. DOI: 10.1371/journal.pone.0012458
    Species: Human
    Sample Type: Conditioned Media
  25. Rosenzweig D., Gawri R., Krock E., Ouellet J., Stone L., et al. High Mechanical Strain of Intervertebral Disc Cells Promotes Secretion of Inflammatory Factors Associated with Disc Degeneration and Pain. Global Spine Journal, Conference Poster Presentation
    Species: Human
    Sample Type: Conditioned Media
  26. Moon MH, Kim SY, Kim YJ, Kim SJ, et al. Human Adipose Tissue-Derived Mesenchymal Stem Cells Improve Postnatal Neovascularization in a Mouse Model of Hindlimb Ischemia. Cell Physiol Biochem. 2006; 17:279-290.
    Species: Human
    Sample Type: Conditioned Media
  27. Jose S., Hughbanks ML., Binder BY., Ingvale GC., Leach JK. Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. Acta Biomater. 2014 May;10(5):1955-64. doi: 10.1016/j.actbio.2014.01.020
    Species: Human
    Sample Type: Bone Marrow Derived Meschencymal Stem Cells embedded in a hydrogel media
  28. Etulain J., Negrotto S., Tribulatti M., Croci D., Carabelli J., et al. Control of Angiogenesis by Galectins Involves the Release of Platelet-Derived Proangiogenic Factors. PLOS One, Published: April 30, 2014 DOI: 10.1371/journal.pone.0096402 [Epub Ahead of Print]
    Species: Human
    Sample Type: Human Platelets, cultured media
  29. Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice
    Species: Mouse
    Sample Type: Tissue Homogenate
  30. Vulesevic B., Mcneill B., Geoffrion M., Kuraitis D., McBane J., et al. Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice. Cardiovascular Research (2014) 101 (2): 306-316. doi: 10.1093/cvr/cvt259
    Species: Mouse
    Sample Type: Hindlimb Tissue Homogenates
  31. Etulain J., Negrotto S., Tribulatti M., Croci D., Carabelli J., et al. Control of Angiogenesis by Galectins Involves the Release of Platelet-Derived Proangiogenic Factors. PLOS One, Published: April 30, 2014 DOI: 10.1371/journal.pone.0096402 [Epub Ahead of Print]
    Species: Human
    Sample Type: Human Platelets, cultured media
  32. Blansfield J, Caragacianu D, Alexander H, Tangrea M, Morita S, et al. Combining Agents that Target the TumorMicroenvironment Improves the Efficacy of Anticancer Therapy. Clin Cancer Res. 2008;14(1):270?208.
    Species: Mouse
    Sample Type: Tissue Homogenate