Angiotensin II

CODE:  331-10042

Molecule Information

Chemical Name
Angiotensin II
CAS Number
Molecular Weight


100.2mg/mL in H2O, <2.09mg/mL in DMSO


Desiccate at -20°C


Cell experiment: [1]

Cell lines

Vascular smooth muscle cells

Preparation method

The solubility of this peptide in sterile water is >10 mM. Stock solution should be splited and stored at -80°C for several months.

Reaction Conditions

100 nM, 4 hours


Treatment of Angiotensin II caused a large increase in both NADH and NADPH oxidase activity, both in terms of initial rate and peak response. The increase in oxidase activity was not apparent until ~ 1 hour and continued to increase for at least 6 hours.

Animal experiment: [2]

Animal models

C57BL/6J (apoE-/- ) mice

Dosage form

Drugs were delivered through the minipumps placed into the subcutaneous space in the back of the neck. 500 or 1000 ng/min/kg for 28 days.


Ang II infusion promotes the development of abdominal aortic aneurysms. The region in the abdominal aorta from an Ang II-infused mouse was markedly increased in size. The tissue encompassing this region was resistant to the dissection process typically used to remove adventitial tissue. The bulbous aortic abdominal shape occurred in 20% and 33% of mice in the groups infused with 500 and 1,000 ng/min/kg of Ang II, respectively.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1] Griendling K K, Minieri C A, Ollerenshaw J D, et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation research, 1994, 74(6): 1141-1148.

[2] Daugherty A, Manning M W, Cassis L A. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. Journal of Clinical Investigation, 2000, 105(11): 1605-1612.