Rabbit Anti-Human ATXN7 (Center)

Rabbit Anti-Human ATXN7 (Center) Antibody, 400 ul

$408.00  
102-13196
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Antigen Information

Accession Number:
  • O15265
Gene ID:
  • 6314
Gene Symbols:
  • ATXN7
Protein Name & Synonyms:
ATXN7 (Center)
Target Species:
  • Human

Antibody Specifications

Concentration:
0.5 mg/ml
Preparation:
This ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the Central region of human ATXN7.
Species Reactivity:
Human
Clonality:
Polyclonal

Introduction

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

Specificity

Predicted Reactivity
Mouse
Other Names
ATXN7; SCA7; Ataxin-7; Spinocerebellar ataxia type 7 protein
NCBI Accession #
NP_000324.1;NP_001121621.2;NP_001170858.1
Other Accession #
Q8R4I1; NP_000324.1; NP_001170858.1

Format

Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
95451
Recommended Dilutions
WB: 1:1000
ATXN7 Antibody (Center) (Cat# 102-13196) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.