PI3K-AKT Signaling Pathway

The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of stimuli and controls fundamental cellular processes such as apoptosis, metabolism, proliferation, protein synthesis, growth, and survival. Dysregulation of this pathway is implicated in a number of disease states including cardiovascular and neurological disease, diabetes, and particularly cancer. This has led to the development of a number of small molecule inhibitors of both PI3K and Akt for use in therapeutic treatment of some of these diseases.

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    Qiao L, Hu S, Liu S, et al. microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. J Clin Invest. 2019;129(6):2237-2250. Published 2019 Apr 29. doi:10.1172/JCI123135
    Species: Human
    Sample type: Cell Lysate (iCM, H9C2, HCF, HUVEC cells )

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    Yang Y, Wang J, Guo S, et al. Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS-AMPK-mTORC1-autophagy pathway. Redox Biol. 2020;32:101501. doi:10.1016/j.redox.2020.101501
    Species: Mouse
    Sample type: Conditioned Media

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    Wang N., Rayes R., Elahi S., et al. The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. Mol Cancer Ther. 2015 Apr;14(4):982-93. doi: 10.1158/1535-7163.MCT-14-0751.
    Species: Mouse
    Sample type: Cell Lysate (Metastatic colon carcinoma cell lines MC-38 and Lewis lung carcinoma H-59 cells.)

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    Luszczak, S., Simpson, B.S., Stopka-Farooqui, U. et al. Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer. Sci Rep 10, 14380 (2020). https://doi.org/10.1038/s41598-020-71263-9
    Species: Human, Mouse
    Sample type: Conditioned media (cell culture media)

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    Luszczak S, Simpson BS, Stopka-Farooqui U, Sathyadevan VK, Echeverria LMC, Kumar C, Costa H, Haider A, Freeman A, Jameson C, Ratynska M, Ben-Salha I, Sridhar A, Shaw G, Kelly JD, Pye H, Gately KA, Whitaker HC, Heavey S. Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer. Sci Rep. 2020 Sep 1;10(1):14380. doi: 10.1038/s41598-020-71263-9. Erratum in: Sci Rep. 2020 Nov 11;10(1):19870. PMID: 32873828; PMCID: PMC7463239.
    Species: Human
    Sample type: Conditioned Media

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    Zhang, Dan, et al. “MALAT1 is involved in the pathophysiological process of PCOS by modulating TGF? signaling in granulosa cells.” Molecular and cellular endocrinology 499 (2020): 110589.
    Species: Human
    Sample type: Cell Lysate (PCOS )

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Related Research Areas

MAPK Pathway

The mitogen-activated protein kinase (MAPK) signaling pathway is activated by a number of extra and intracellular stimuli including cytokines, growth factors, and hormones as well as stressors such as oxidative and ER stress.

NF-kB Pathway

The nuclear factor-κB (NF-κB)/Rel family members function as dimeric transcription factors that play important roles in regulating the expression of cytokines, growth factors, and inhibitors of apoptosis.

Apoptosis

Apoptosis is the process of programmed cell death, involving a series of biochemical events leading to characteristic cell morphology changes and eventual cell death.