IGF-1 Signaling Pathway

The insulin-like growth factor (IGF) signaling pathway functions in mediating cell proliferation, apoptosis, differentiation, survival, metabolism, and migration. These interactions provide a potent system that regulates many other processes such as cardiovascular, muscle, bone, and brain development. The IGF system comprises of IGF-1 and IGF-2 and their respective receptors, IGF-1 receptor and IGF-2 receptor, as well as six binding proteins, IGFBP1-6. The IGF signaling pathway has been implicated in aging, since it has important roles in many of the functions necessary for growth, metabolism and fertility. It has also been implicated in neurodegeneration, diabetes, and cancer progression.

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Related Products

  1. Human IGF Signaling Array Q1

    Quantibody® Human Insulin-like Growth Factor Signaling Array 1 Kit. Detects 10 Human Cytokines. Suitable for all liquid sample types.
  2. Human IGF-1 ELISA

    RayBio® Human IGF-1 ELISA Kit for cell culture supernatants, plasma, and serum samples.

    Lead time: Typically ships within 1-2 business days. No Friday shipments.
  3. Human Phosphotyrosine IGF-1R ELISA
    Semi-quantitatively detects phosphorylated IGF-1R in lysate samples
  4. Human Apoptosis Array C1
    Membrane-based antibody array for detection 43 apoptosis biomarkers, including Caspase 3, Caspase 8, bad, bax, bcl-2, etc.
  5. Mouse Growth Factor Array C2

    RayBio® C-Series Mouse Growth Factor Antibody Array 2 Kit. Detects 20 Mouse Growth Factors. Suitable for all liquid sample types.
  6. Human IGF Signaling Array GS1

    G-Series Human IGF Signaling Array 1 Kit. Semi-quantitative measurement of 10 human IGF family proteins. Suitable for all liquid sample types.

Featured Publications

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    Schwartz S., Wongvipat J., Trigwell C., et al. Feedback Suppression of PI3Ka Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kb. Cancer Cell. 2015 Jan 12;27(1):109-22. doi: 10.1016/j.ccell.2014.11.008
    Species: Human
    Sample type: Conditioned Media (LNCaP cells treated with AZD8186)

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    Del Fante, Claudia, et al. “Conditioned Medium Originated From Lethally Irradiated Umbilical Cord Blood-Derived Mononuclear Cells Has Different Pro-Angiogenic Effects Over Mature and Progenitor Endothelial Cells In Vitro.” (2013): 1068-1068.
    Species: Human
    Sample type: Conditioned Media (monnuclear cells)

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    Pezzotti, Giuseppe, et al. “Silicon nitride surface chemistry: a potent regulator of mesenchymal progenitor cell activity in bone formation.” Applied Materials Today 9 (2017): 82-95.
    Species: Human
    Sample type: Conditioned Media (bone marros stromal stem cells)

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Related Research Areas

Apoptosis

Apoptosis is the process of programmed cell death, involving a series of biochemical events leading to characteristic cell morphology changes and eventual cell death.