MAPK Signaling Pathway

The mitogen-activated protein kinase (MAPK) signaling pathway is activated by a number of extra and intracellular stimuli including cytokines, growth factors, and hormones as well as stressors such as oxidative and ER stress. This pathways plays a key role in the regulation of many cellular processes including proliferation, differentiation, the stress response, motility, growth, differentiation, survival, and death. Abnormal MAPK signaling may contribute to increased or uncontrolled cell proliferation and/or resistance to apoptosis. Dysregulation of controlled MAPK signaling has been shown to be important in the development and progression of many diseases including various types of cancer and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

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Related Products

  1. Human/Mouse MAPK Phosphorylation Array
    Detects 17 phosphorylated proteins in human or mouse samples. Suitable for all liquid sample types but intended for use with cell and tissue lysates.
  2. MAPK Pathway Screening Array
    Screen the relative levels of 237 human proteins involved in MAPK signaling pathway. Suitable for serum, plasma, cell culture supernatants, and lysates.
  3. Human/Mouse/Rat Phospho-MKK3 (S189) ELISA

    RayBio® Human/Mouse/Rat Phospho-MKK3 (S189) ELISA Kit. This assay semi-quantitatively measures phosphorylated MKK3 (Ser189) in lysate samples.
  4. Human MKK6/MEK6 ELISA
    Sandwich-based ELISA kit for the quantitative detection of MKK6/MEK6, also known as Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6).
  5. Human Phosphorylation Pathway Profiling Array C55
    Detects 55 phosphorylated human proteins in 5 signaling pathways: MAPK, AKT, JAK/STAT, NFκB, and TGFβ. Suitable for all liquid sample types but intended for use with cell and tissue lysates.
  6. Mouse Apoptosis Signaling Pathway Array C1
    C-Series Mouse Apoptosis Antibody Array 1 Kit. Detects 17 phosphorylated or cleaved mouse Apoptotic Factors. Suitable for all liquid sample types but intended for use with cell and tissue lysates.
  7. Human/Mouse AKT Pathway Phosphorylation Array C1
    Detects 18 different phosphorylated human and mouse proteins crucial to the AKT Pathway

Featured Publications

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    Poling, Holly M., et al. “Mechanically induced development and maturation of human intestinal organoids in vivo.” Nature biomedical engineering 2.6 (2018): 429-442.
    Species: Human
    Sample type: Tissue Lysate

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    Xie Z, Peng M, Lu R, Meng X, Liang W, Li Z, Qiu M, Zhang B, Nie G, Xie N, Zhang H, Prasad PN. Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy. Light Sci Appl. 2020 Sep 15;9:161. doi: 10.1038/s41377-020-00388-3. PMID: 33014356; PMCID: PMC7492464.
    Species: Mouse
    Sample type: Tissue Lysate

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    Yu S., Zhong Q., Chen R., et al. CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways. Cell Death Dis. 2018 Mar 7;9(3):371. doi: 10.1038/s41419-018-0352-0.
    Species: Human
    Sample type: Cell Lysate (Human thyroid cell lines, normal and cancerous; IHH-4, PTC, etc)

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