Goat Anti-Human CD192 (N-term.)

Goat Anti-Human CD192 (N-term.) (0.1 mg)
CODE:  129-10110

Antigen Information

Protein Name & Synonyms:
CD192
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: , 1/1000), Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Goat
Immunogen Sequence:
C-GEEVTTFFDYDYGAPCHKFDVKQ
Species Reactivity:
Human

Specificity

This product specifically recognizes an epitope within the N-terminal (NT) region of human CD192, otherwise known as CCR2 (C-C chemokine receptor type 2), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4.

Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to human CD192 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide C-GEEVTTFFDYDYGAPCHKFDVKQ corresponding to amino acids 17-39 within the N-terminal region of human CD192.
Preservative:
0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin