Goat Anti-Human CD196

Goat Anti-Human CD196 (0.1 mg)

$542.00
129-10115
+

Antigen Information

Protein Name & Synonyms:
CD196
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: , 1/250), Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Goat
Immunogen Sequence:
YFVSVNTSYYSVDSEMLLCSLQEVRQFSR
Species Reactivity:
Human, Mouse

Specificity

This product recognizes human CD196, otherwise known as CCR6 (C-C chemokine receptor type 6), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a specific receptor for the C-C chemokine LARC (Liver and activation-regulated chemokine)/MIP-3alpha, a selective chemoattractant which induces calcium flux in CD196-expressing lymphocytes.

CD196 is preferentially expressed by B cells, memory T cells and immature dendritic cells and plays an important role in B lineage maturation and antigen-driven B cell differentiation. CD196 acts as a co-receptor for HIV1 infection, and is selectively expressed by mucosa-associated non-Hodgkin's lymphoma, making the interaction between CD196 and LARC a potential therapeutic target in these malignancies.

This product cross-reacts with mouse CD196, where linear epitopes are accessible.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to human CD196 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide YFVSVNTSYYSVDSEMLLCSLQEVRQFSR corresponding to amino acids 18-46 of human CD196.
Preservative:
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.