Protein Name & Synonyms:
ELISA (dilution: , 1/250), Immunohistology - Paraffin, Western Blotting
This product recognizes human CD196, otherwise known as CCR6 (C-C chemokine receptor type 6), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a specific receptor for the C-C chemokine LARC (Liver and activation-regulated chemokine)/MIP-3alpha, a selective chemoattractant which induces calcium flux in CD196-expressing lymphocytes.
CD196 is preferentially expressed by B cells, memory T cells and immature dendritic cells and plays an important role in B lineage maturation and antigen-driven B cell differentiation. CD196 acts as a co-receptor for HIV1 infection, and is selectively expressed by mucosa-associated non-Hodgkin's lymphoma, making the interaction between CD196 and LARC a potential therapeutic target in these malignancies.
This product cross-reacts with mouse CD196, where linear epitopes are accessible.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Antiserum to human CD196 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Synthetic peptide YFVSVNTSYYSVDSEMLLCSLQEVRQFSR corresponding to amino acids 18-46 of human CD196.
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin