Goat Anti-Human CD230

Goat Anti-Human CD230 (0.1 ml)

DS-PB-00417
+

Antigen Information

Protein Name & Synonyms:
CD230
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1/10,000, 1/2000), Immunohistology - Paraffin, Western Blotting
Preparation:
Antisera to human PrP27-30 were raised by repeated immunisation of goats with highly purified antigen.
Species Reactivity:
Human, Bovine, ovine and hamster PrPc is highly conserved so cross-reactivity is likely across other species, but not confirmed
Immunohistology:
This product does not require protein digestion pre-treatment of paraffin sections.This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

Specificity

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.

CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.

This product has been shown to stain PrPSc plaques in formalin fixed sections of CJD brain. It also reacts with PrPc.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to human PrP27-30 were raised by repeated immunisation of goats with highly purified antigen.

Immunogen:
Synthetic peptide corresponding to amino acids 79-97 of the N-terminus of human prion protein
Preservative:
0.1%Sodium Azide

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.