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770-729-2992
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Product Specifications
Size:
0.1 mg
Protein Information
Protein Name & Synonyms:
CDKN2A
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 0.1, 1.0ug/ml), Western Blotting
Concentration (lot specific):
IgG concentration 0.5mg/ml
Preparation:
Antisera to CDKN2A (isoform 1) were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human
This product detects a band of approximately 16-18kDa in A431 and Hela cell lysates.
Specificity
This product detects an epitope within the C-terminal (CT) region of cyclin-dependent kinase inhibitor 2A (CDKN2A). CDKN2A is a 16kD protein which belongs to the CDKN2 cyclin dependent kinase inhibitor family. It acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified
Preparation
Antisera to CDKN2A (isoform 1) were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Peptide with sequence C-HARIDAAEGPSDIPD from C-terminal of CDKN2A.
Preservative:
| 0.02% | Sodium Azide (NaN3) |
| 0.5% | Bovine Serum Albumin |
Expiration:
12 months from the date of shipment when stored properly.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
