Goat Anti-Human Cholesterol 24-Hydroxylase (C-term)

Goat Anti-Human Cholesterol 24-Hydroxylase (C-term)

$542.00
DS-PB-02212
+

Antigen Information

Protein Name & Synonyms:
Cholesterol 24-Hydroxylase
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: , 1/3000), Western Blotting
Preparation:
Antisera to cholesterol 24-hydroxylase (CT) were raised by repeated immunisations of goats with highly purified antigen.
Species Reactivity:
Human

This product detects a band of approximately 58kDa in human Alzheimer diseased brain lysates.

Specificity

This product recognizes cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system.

P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to cholesterol 24-hydroxylase (CT) were raised by repeated immunisations of goats with highly purified antigen.

Immunogen:
Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
Preservative:
0.09%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.