Goat Anti-Human ErbB3 / HER3 (C-term)

Goat Anti-Human ErbB3 / HER3 (C-term)

$571.00
DS-PB-02234
+

Antigen Information

Protein Name & Synonyms:
ErbB3 / HER3
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 0.1, 0.3ug/ml), Western Blotting
Concentration:
IgG concentration 0.5 mg/ml
Preparation:
Antisera to human ErbB3 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human

This product detects a band of approximately 150kDa in Jurkat cell lysates. A minimum incubation time of 1 hour is recommended with this antibody.

Specificity

This product detects an epitope within the C-terminal (CT) region of ErbB3 isoform 1. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, and has a molecular weight of 150kD. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain, and can therefore only convey the signal through heterodimerisation with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of cellular pathways, thus leading to proliferation or differentiation.

Amplification of this gene and/or over expression of its protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. In breast cancer it has been shown to dimerize with ErbB2 to drive tumour cell proliferation.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified

Preparation

Antisera to human ErbB3 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
Peptide sequence C-HSRLFPKANAQRT corresponding to the C-terminal of ErbB3 isoform 1(NP_001973.2).
Preservative:
0.02%Sodium Azide
0.5%Bovine Serum Albumin

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.