Goat Anti-Human GFAP (C-term)

Goat Anti-Human GFAP (C-term)

$571.00
DS-PB-02261
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Antigen Information

Protein Name & Synonyms:
GFAP
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1.0, 3.0ug/ml), Western Blotting
Concentration:
IgG concentration 0.5mg/ml
Preparation:
Antiserum to human GFAP (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human, Mouse

This product detects a band of approximately 48kDa in mouse brain cell lysates.

Specificity

This product recognizes an epitope within the C-terminal (CT) region of human GFAP (glial fibrillary acidic protein), a class III intermediate filament (IF) protein specifically expressed by glial cells or cells of glial origin e.g astrocytes, ependymal cells and Schwann cells.

GFAP plays a role in several cellular functions within the central nervous system (CNS), including cell structure and stability, communication, motility and mitosis, and is rapidly synthesized during astrogliosis, following trauma/injury. Mutations in the GFAP gene are responsible for the rare autosomal dominant disorder known as Alexander disease, resulting in the destruction of brain white matter and the formation of fibrous, eosinophilic deposits known as Rosenthal fibers. Characteristics of this disease are associated with transgenes and other mutation types in mouse.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified

Preparation

Antiserum to human GFAP (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
Peptide sequence C-DGEVIKESKQEHKD from the C-terminal region of GFAP (NP_002046.1).
Preservative:
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.