Goat Anti-Human MIP-1 alpha / CCL3

Goat Anti-Human MIP-1 alpha / CCL3

$571.00
DS-PB-01334
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Antigen Information

Protein Name & Synonyms:
MIP-1 alpha / CCL3
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 0.1, 0.2ug/ml), Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human MIP-1 alpha were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.
Reconstitution:
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Species Reactivity:
Human

Specificity

This product is specific for human MIP-1 alpha, otherwise known as CCL3, a 69 amino acid member of the CC chemokine family which plays a critical role in hematopoiesis and is shown to signal through the chemokine receptors CCR1, CCR4 and CCR5.

MIP-1 alpha is also involved in host defence against invading pathogens, acting as a regulator of activation and trafficking of inflammatory cells, such as macrophages, NK cells, granulocytes, dendritic cells and CD8+ lymphocytes. The recruitment of inflammatory cells by MIP-1 alpha, has been linked with the pathogenesis of several diseases, including rheumatoid arthritis, H. pylori associated gastritis and bacterial meningitis.

The secretion of MIP-1 alpha by CD8+ lymphocytes has been shown to act as a major HIV-suppressive factor (HIV-SF) through binding to CCR5, identified as a coreceptor for HIV-1 target cell entry.

Storage/Stability

Prior to reconstitution store at +4 °C.
After reconstitution store at -20 °C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Format Type:
Purified

Preparation

Antisera to human MIP-1 alpha were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Recombinant human MIP-1 alpha
Preservative:
None present

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.