Protein Name & Synonyms:
ELISA (dilution: , 2.5ug/ml), Immunohistology - Paraffin
This product recognizes human NACHT, LRR and PYD domains-containing protein 3 (NALP3), a cytoplasmic protein belonging to the NLRP family.
NALP3 is involved in inflammation and immune response. Research indicates that NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis.
Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
TRIS buffered saline
Antisera to human NALP3 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Synthetic peptide sequence corresponding to C-EKPELTVVFEPSW from the C Terminus of Human NALP3 (NP_004886).
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin