Goat Anti-Human PAI-1

Goat Anti-Human PAI-1

$571.00
DS-PB-02306
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Antigen Information

Protein Name & Synonyms:
PAI-1
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 0.1, 0.3ug/ml), Western Blotting
Concentration:
IgG concentration 0.5 mg/ml
Preparation:
Antisera to human PAI-1 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human

This product detects a band of approximately 45kDa in human duodenum, liver and lung lysates. A minimum incubation time of 1 hour is recommended with this antibody.

Specificity

This product recognizes an epitope within the internal region of human PAI-1, a 45kD serine protease inhibitor which is the principle inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA). Plasminogen activator inhibitor-1 is also known as Serpine1, and due to its inhibitor function of tPA and uPA, is an inhibitor of fibrinolysis.

PAI-1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity and the metabolic syndrome. Defects in serpine1 are characterized by abnormal bleeding.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified

Preparation

Antisera to human PAI-1 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
Peptide with sequence C-GFKIDDKGMAPALRH, corresponding to the internal region of PAI-1 (NP_000593.1).
Preservative:
0.02%Sodium Azide
0.5%Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.