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770-729-2992
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Product Specifications
Size:
0.1 mg
Protein Information
Protein Name & Synonyms:
SNAP-25
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 0.01, 0.03ug/ml), Western Blotting
Concentration (lot specific):
IgG concentration 0.5 mg/ml
Preparation:
Antisera to human SNAP-25 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human
This product detects a band of approximately 22kDa in human and mouse brain lysates. A minimum incubation time of 1 hour is recommended with this antibody.
Specificity
This product detects an epitope within the C-terminal (CT) of human synaptosomal-associated protein, 25kD (SNAP-25). SNAP-25 is a presynaptic plasma membrane protein which is essential for Ca2+-regulated exocytosis of neurotransmitters. SNAP-25 has been shown to bind to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release.
SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis. This product is expected to recognize both isoforms.
SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, whilst SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms.
SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis. This product is expected to recognize both isoforms.
SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, whilst SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified
Preparation
Antisera to human SNAP-25 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen:
Peptide sequence C-DEANQRATKMLGSG corresponding to the C-terminus of SNAP-25 (NP_003072.2, NP_570824.1).
Preservative:
| 0.02% | Sodium Azide |
| 0.5% | Bovine Serum Albumin |
Expiration:
12 months from the date of shipment when stored properly.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
