Goat Anti-Human SYK

Goat Anti-Human SYK

$582.00
DS-PB-02344
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Antigen Information

Protein Name & Synonyms:
SYK
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1.0, 3.0ug/ml), Western Blotting
Concentration:
IgG concentration 0.5mg/ml
Preparation:
Antisera to SYK were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

This product detects a band of approximately 70kDa in human bone marrow, lymph node and spleen lysates.

Specificity

This product detects an epitope within the internal region of SYK, a 70kD non-receptor protein tyrosine kinase whose role differs in hematopoietic and non hematopoietic stem cells. In hematopoietic cells SYK is involved in the proximal signalling downstream of activated immunoreceptors (BCR, TCR, Fc receptors), thereby orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

In epithelial cells SYK appears to function as a negative regulator of related events. Furthermore, SYK has been shown to promote expression or secretion of inflammation-related molecules in lung epithelial cells.

SYK appears to be required for vascular integrity during development, thus, manipulation of SYK function in endothelial cells could potentially modulate tumour-associated angiogenesis. SYK also has been shown to interact with Epstein-Barr virus LMP2A.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified

Preparation

Antisera to SYK were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence.
Preservative:
0.02%Sodium Azide (NaN3)
0.5%Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.