Goat Anti-Human Troponin I

Goat Anti-Human Troponin I

$420.00
DS-PB-02013
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Antigen Information

Protein Name & Synonyms:
Troponin I
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, ELISA, Immunofluorescence, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human cardiac troponin I were raised by repeated immunisations of goats with highly purified antigen.
Species Reactivity:
Human

Specificity

This product recognizes human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT).

The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement.

The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to human cardiac troponin I were raised by repeated immunisations of goats with highly purified antigen.

Immunogen:
Native human cardiac troponin I, purity greater than 98%.
Preservative:
0.09%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.