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Antigen Information
Protein Name & Synonyms:
Urokinase
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 0.3, 1.0ug/ml), Western Blotting
Concentration:
IgG concentration 0.5mg/ml
Preparation:
Antisera to Urokinase were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human
This product detects a band of approximately 48kDa in KEH 293 cell lysates.
Specificity
This product detects an epitope within the C-terminal of urokinase, a potent 50kD serine protease which is also known as urokinase plasminogen activator (uPA). uPA cleaves and activates plasminogen to form plasmin and is involved in extracellular cellular matrix degradation and cell signalling. Recent studies have implicated uPA and its receptor in the pathogenesis of inflammation and immunity.
A specific polymorphism in the gene encoding uPA may be associated with late-onset Alzheimer's disease. The levels of uPA, uPAR and its soluble fragments have also been found to be increased in tissues, plasma and other body fluids of cancer patients and to be markers of cancer development and metastasis.
A specific polymorphism in the gene encoding uPA may be associated with late-onset Alzheimer's disease. The levels of uPA, uPAR and its soluble fragments have also been found to be increased in tissues, plasma and other body fluids of cancer patients and to be markers of cancer development and metastasis.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified
Preparation
Antisera to Urokinase were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Peptide with sequence C-HFLPWIRSHTKEEN from the C-terminal of the Urokinase sequence.
Preservative:
| 0.02% | Sodium Azide (NaN3) |
| 0.5% | Bovine Serum Albumin |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
