Goat Anti-Mouse CD197

Goat Anti-Mouse CD197 (50 ug)

$542.00
129-10116
+

Antigen Information

Protein Name & Synonyms:
CD197
Target Species:
  • Mouse

Antibody Specifications

Applications:
ELISA (dilution: 1/1000, ), Flow Cytometry, Functional Assays, Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Goat
Species Reactivity:
Mouse, Human

Specificity

This product recognizes mouse CD197, otherwise known as CCR7 (C-C chemokine receptor type 7), a type III transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, expressed by various lymphoid tissues, activated B and T cells, naive T cells, NK cells and dendritic cells (DCs), which acts a high-affinity receptor for the chemokines MIP-3beta (CCL19) and CCL21.

Ligand binding of CD197 plays a vital role in the homing of naive T cells and antigen-loaded DCs into secondary organs. Expression of CD197 is strongly up-regulated in B cells infected with Epstein-Barr virus (EBV) and T cells infected with herpesvirus 6 or 7. CD197 can be used in research studies to distinguish between central memory and effector memory T cells.

This product is reported as suitable for use in immunocytochemistry.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to mouse CD197 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide DPGKPRKNVLVVALLVIFQVC corresponding to amino acids 2-22 of mouse CD197.
Preservative:
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.