Goat Anti-Mouse CD289 (N-term.)

Goat Anti-Mouse CD289 (N-term.) (0.1 mg)

129-10143
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Antigen Information

Protein Name & Synonyms:
CD289
Target Species:
  • Mouse

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
2.0mg/ml
Host Species:
Goat
Immunogen Sequence:
LSLKYNNLTKVPRQLPPSLEY-C
Species Reactivity:
Mouse, Human

Specificity

This product specifically recognizes an epitope within the N-terminal (NT) region of CD289, otherwise known as Toll-like receptor 9 (TLR9), a type I transmembrane glycoprotein and member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response.

CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity. CD289 has been shown to play a role in defence against systemic mouse cytomegalovirus infection.

This product is reported as suitable for use in immunocytochemistry on acetone fixed cells.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to mouse CD289 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminal region of mouse CD289.
Preservative:
0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.