Mouse anti-Human EGF Receptor Antibody [Sodium Azide Free]

Mouse anti-Human EGF Receptor Antibody [Sodium Azide Free]

$488.00  
188-10073-SAF
+

Antigen Information

Accession Number:
  • P00533
Gene ID:
  • 1956
Gene Symbols:
  • EGFR
  • ERBB
  • ERBB1
  • HER1
Protein Name & Synonyms:
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Target Species:
  • Human

Antibody Specifications

Applications:
Functional Activity (Inhibition): antibody blocks EGF receptor activation, inhibits A431 cell proliferation, arrests tumor growth in vivo, affinity purification
IP: 1-2µg/500ug protein lysate
FACS: 0.5-1ug/million cells
Concentration:
1 mg/ml in 1X PBS (pH 7.4), BSA free, sodium azide free
Domain/Region/Terminus:
Cell surface
Host Species:
Mouse
Preparation:
Microsomes from A431 cells were used as the immunogen for this antibody.
Purity:
Protein G purified monoclonal antibody
Species Reactivity:
Human. Does not react with mouse and rat. Other species not known.
Isotype:
Mouse IgG2a, kappa

Description

This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor. EGFR is type I receptor tyrosine kinase with sequence homology to ErbB2, -3 -4 or HER2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Storage

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.

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