Formalin-fixed, paraffin-embedded human melanoma stained with TYRP1 antibody (TYRP1/807)

Mouse anti-Human/Mouse TYRP1 Antibody (TRP)

Mouse anti-Human/Mouse TYRP1 Antibody (TRP)

$198.00  
188-10733-1
+

Antigen Information

Accession Number:
  • P17643
Gene ID:
  • 7306
Gene Symbols:
  • CAS2
  • TYRP
  • TYRP1
  • TYRRP
Protein Name & Synonyms:
5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)
Target Species:
  • Human
  • Mouse

Antibody Specifications

Applications:
Flow Cytometry: 1-2ug/million cells in 0.1ml
Immunofluorescence: 3-6ug/ml
Immunohistochemistry (FFPE): 3-6ug/ml for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Concentration:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Domain/Region/Terminus:
Cytoplasmic
Host Species:
Mouse
Preparation:
Recombinant full-length human protein was used as the immunogen for the TYRP1 antibody.
Purity:
Protein G affinity chromatography
Species Reactivity:
Human and Mouse. Other species not tested.
Isotype:
Mouse IgG2a, kappa

Description

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Storage

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.