Western blot testing of HeLa lysate with SUMO2/3 antibody.

Mouse anti-Human SUMO2/3 Antibody

Mouse anti-Human SUMO2/3 Antibody

$198.00
188-11343-1
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Antigen Information

Accession Number:
  • P61956,P55854
Gene ID:
  • 6612
  • 6613
Gene Symbols:
  • SMT3A
  • SMT3B
  • SMT3H1
  • SMT3H2
  • SUMO2
  • SUMO3
Protein Name & Synonyms:
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B),Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Target Species:
  • Human

Antibody Specifications

Applications:
IF: 0.5-1ug/ml
WB: 0.5-1ug/ml
IHC (FFPE): 0.5-1ug/ml for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Concentration:
0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Domain/Region/Terminus:
Predominantly nuclear with some cytoplasmic
Host Species:
Mouse
Preparation:
Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody. This antibody reacts with both SUMO2 and SUMO3.
Purity:
Protein G purified
Species Reactivity:
Human, broad species reactivity.
Isotype:
Mouse IgG1, kappa

Description

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO1, 2 and 3, belong to the ubiquitin-like protein family. SUMO proteins are synthesized as precursors that undergo processing before conjugation to target proteins. Sumoylation targets for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. SUMO2/3 contribute to a greater percentage of protein modification than does SUMO1 and they can form polymeric chains. In addition, SUMO3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Storage

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.