Discovery in the Post-Genomic Age
How to use proteomic assays to discover more and publish faster
In recent years, the healthcare industry has seen increasing interest and expanding implementation of telemedicine and remote options for care. The ongoing COVID-19 pandemic has caused more rapid adoption of such practices. For example, the US Centers for Medicare and Medicaid Services broadened the range of telemedicine services it reimburses…
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19) which was first reported in Wuhan, China in December 2019 [1]. Currently, the United States has become one of the most impacted regions with confirmed cases totaling more than 5.6 million and with more than 175,000 deaths [2]. The…
In COVID-19 cases of greatest severity, a defective host immune response appears to play a central role. In particular, the acute respiratory distress syndrome (ARDS) and organ failure that typify a severe disease course are accompanied by elevated levels of IL-2, IL-7, G-CSF, IFN-γ, IP-10, MCP-1, MIP1-α, and TNF-α [1].…
Introduction The coronavirus disease 2019 (COVID-19) is caused by the highly contagious SARS-CoV-2 virus. [1] Some infected individuals are asymptomatic while others experience very severe symptoms that can result in death (Figure 1). [2] More specifically, those over 55 years old or have underlying conditions are especially vulnerable to developing…
Introduction In December 2019, the first cases of patients with severe acute respiratory syndrome (SARS) caused by the novel coronavirus, SARS-CoV-2, were reported in China. [1] In mid-March 2020, the World Health Organization (WHO) declared COVID-19 (COronaVIrus Disease of 2019) a pandemic. By mid-May 2020, there were ~4.5 million confirmed…
Introduction Protein phosphorylation is the most well-studied post translational modification (PTM), in which a phosphoryl group from adenosine triphosphate (ATP) is covalently attached to a serine (~86%), threonine (~12%), or tyrosine (~2%) by a kinase and removed by a phosphatase (Figure 1). [1] Phosphorylation at other amino acids have also…