Discovery in the Post-Genomic Age
How to use proteomic assays to discover more and publish faster
Introduction In December 2019, the first cases of patients with severe acute respiratory syndrome (SARS) caused by the novel coronavirus, SARS-CoV-2, were reported in China. [1] In mid-March 2020, the World Health Organization (WHO) declared COVID-19 (COronaVIrus Disease of 2019) a pandemic. By mid-May 2020, there were ~4.5 million confirmed…
Introduction Protein phosphorylation is the most well-studied post translational modification (PTM), in which a phosphoryl group from adenosine triphosphate (ATP) is covalently attached to a serine (~86%), threonine (~12%), or tyrosine (~2%) by a kinase and removed by a phosphatase (Figure 1). [1] Phosphorylation at other amino acids have also…