Discovery in the Post-Genomic Age
How to use proteomic assays to discover more and publish faster
Telomere shortening leads to the induction of DNA damage signaling, which has been associated with aging and stem cell decline. In this study, the authors used a cytokine array to help determine that telomere dysfunction impaired mesenchymal progenitor cell function, reduced the capacity of bone marrow stromal cells to maintain…
The authors of this study identify DNA damage signaling as a key mediator of vascular smooth muscle cell (VSMC) osteogenic differentiation in a model of calcification and aging. They demonstrate that the accumulation of prelamin A, a nuclear lamin protein that plays an important role in VSMC calcification, interferes with…
In this study the authors investigated induction of senescence in human melanoma as a potential cancer therapeutic approach. They found that inhibition of aurora kinase induced senescence which resulted from the DNA damage response. The use of an antibody array indicated that this DNA damage mediated IKKβ/NF-κB activation and promoted…