Cytokine Arrays Can Help Advance Your Research

In this study the authors investigated induction of senescence in human melanoma as a potential cancer therapeutic approach. They found that inhibition of aurora kinase induced senescence which resulted from the DNA damage response. The use of an antibody array indicated that this DNA damage mediated IKKβ/NF-κB activation and promoted senescent melanoma cells to secrete IL-6, IL-8 [CXCL8] and GRO [CXCL1, 2 and 3] in vitro and in vivo, which are associated with the pro-inflammatory response and recruitment of neutrophils and macrophages to senescent tumor cells. These macrophages boosted the immune response and played a critical role in the clearance of senescent tumor cells.

Liu, Yan, et al. “Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence.” EMBO molecular medicine 5.1 (2013): 149-166.

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