MMP Arrays

RayBiotech offers 2 different MMP Antibody Arrays for detecting 10 matrix metalloproteinases. See the below product listings for more information.

 
  Human MMP Array Q1 (QAH-MMP-1)
Quantibody Arrays - Quantitative, Sandwich-Based, Glass Slide Antibody Arrays
Detects 10 Human Matrix Metalloproteinases:
MMP-1, MMP-10, MMP-13, MMP-2, MMP-3, MMP-8, MMP-9, TIMP-1, TIMP-2, TIMP-4
Manual         Quantibody Overview

 

  Human MMP Array C1 (AAH-MMP-1)
C-Series Arrays - Semi-Quantitative, Sandwich-Based, Membrane Antibody Arrays
Detects 10 Human Matrix Metalloproteinases:
MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, TIMP-1, TIMP-2, TIMP-4
Manual         C-Series Overview

 

Product Highlights

  • Quantitative or Semi-Quantitative level of 41 Growth Factors are detected simultaneously
  • No need to perform individual immunoprecipitations or Western Blot
  • Reliable results with wide range of cell lines
  • High specificity, sensitivity and reproducibility
  • Membrane formats - No special equipment required
  • Glass slide formats - Fluorescent laser scanner is needed*
  • Many choices: chemiluminescence or fluorescence detection system; Membrane or glass chip
 

*Click here for a list of compatible laser scanners. Raybiotech now offers free glass slide scanning and data extraction services (click to learn more!).

 

How It Works

The principle of how an antibody array works

 

Reference List


  1. Martin G., Asensi V., Montes H., Collazos J., Alvarez V., Carton J., Taboada F., Valle-Garay E. Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients. Scientific Reports 4, 5002. doi:10.1038/srep05002.
    Species: Human
    Sample Type: Plasma

  2. Chia C., Kumari U., Casey P. Breast cancer cell invasion mediated by Galpha12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2. Journal of Molecular Signaling 2014, 9:6 doi:10.1186/1750-2187-9-6
    Species: Human
    Sample Type: Conditioned Media

  3. Kanangat S, Postlethwaite A, Hasty K, Kang A, et al. Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureau: Implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Res Ther. 2006;8:R176. Available at http://arthritis-research.com/content/8/6/R176. Last accessed January 17, 2008.
    Species: Human
    Sample Type: Conditioned Media

  4. Chandrasekar B, Mummidi S, Mahimainathan L, Patel DN, Baile SR, et al. Interleukin-18-induced Human Coronary Artery Smooth Muscle Cell Migration is Dependent on NF-kB- and AP-1-mediated Matrix Metalloproteinase-9 Expression and is inhibited by Atorvastatin. J Biol Chem. 2006:281(22):15099-15109.
    Species: Human
    Sample Type: Conditioned Media

  5. Del Carlo M, Schwartz D, Erickson EA, Loeser RF. Endogenous production of reactive oxygen species is required for stimulstion of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radical Biol Med. 2007;42:1350?1358.
    Species: Human
    Sample Type: Conditioned Media

  6. Sze S, Kleijn D, Lai R, Tan E, Zhao H,et al.Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells.Mol Cell Proteomics. 2007; 6: 1680-1693
    Species: Human
    Sample Type: Conditioned Media

  7. Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, et al. IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kB, and AP-1 activation. Am J Physiol Heart Circ Physiol. 2007;293:H3356?H3365.
    Species: Human
    Sample Type: Conditioned Media

  8. Smith GN Jr, Mickler EA, Payne KK, Lee J, et al. Lung Transplant Metalloproteinase Levels are Elevated Prior to Bronciolitis Obliterans Syndrome. Am J Transplant. 2007;7:1656?1661.
    Species: Human
    Sample Type: BAL Fluid

  9. Raghu H., Lakka S., Gondi C., Mohanam S., et al. Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines. PLOS One, Published: August 27, 2010. DOI: 10.1371/journal.pone.0012458
    Species: Human
    Sample Type: Conditioned Media

  10. Regenerative Potential of Decellularized Porcine Nucleus Pulposus Hydrogel Scaffolds: Stem Cell Differentiation, Matrix Remodeling, and Biocompatibility Studies
    Species: Human
    Sample Type: Conditioned Media

  11. Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression
    Species: Human
    Sample Type: Conditioned Media

  12. Lisboa RA, Andrade MV, Cunha-Melo. Toll-like receptor activation and mechanical force stimulation promote the secretion of matrix metalloproteinases 1, 3 and 10 of human periodontal fibroblasts via p38, JNK and NF-kB. Arch Oral Biol. 2013;58(6):731?739.
    Species: Human
    Sample Type: Conditioned Media

  13. Vesey DA, Suen JY, Seow V, et al. PAR2-induced inflammatory responses in human kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F737-F750.
    Species: Human
    Sample Type: Conditioned Media

  14. PAR2-induced inflammatory responses in human kidney tubular epithelial cells
    Species: Human
    Sample Type: kidney tubular epithelial Conditioned Media

  15. Zhu S., Hong J., Tripathi M., Sehdev V., et al. Regulation of CXCR4-Mediated Invasion by DARPP-32 in Gastric Cancer Cells. Mol Cancer Res January 2013 11; 86
    Species: Human
    Sample Type: Conditioned Media

  16. Ichikawa T., Sugiura H., Koarai A., Minakata Y., Kikuchi T., Morishita Y., et al. TLR3 Activation Augments Matrix Metalloproteinase Production through Reactive Nitrogen Species Generation in Human Lung Fibroblasts. The Journal of Immunology April 23, 2014 1302919 [Epub Ahead of Print]
    Species: Human
    Sample Type: Human Fetal Lung Fibroblasts (HFL-1) and U2-OS Conditioned Media

  17. Patil P., Joshi M., Kuna Vijay., Xu B., Johannesson L., Olausson M., Sumitran-Holgersson S. CD271 identifies functional human hepatic stellate cells, which localize in peri-sinusoidal and portal areas in liver after partial hepatectomy. [Published same as previous]
    Species: Human
    Sample Type: Conditioned Media

  18. Carduner L., Leroy-Dudal J., Picot CR., Gallet O., Carreiras F., et al. Ascites-induced shift along epithelial-mesenchymal spectrum in ovarian cancer cells: enhancement of their invasive behavior partly dependant on ?v integrins. Clinical and Experimental Metastasis. Jun 2014 Epub Ahead of Print.
    Species: Human

  19. Krohn A., et al. Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-Mesenchymal Transition (EMT) and DNA Methylation Changes. PLOS One Published: June 24, 2014 DOI: 10.1371/journal.pone.0100249
    Species: Human
    Sample Type: Conditioned Media

  20. Orgaz J., et al. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nature Communications 5, Article number:4255. doi:10.1038/ncomms5255
    Species: Human
    Sample Type: Conditioned Media

  21. Sakimoto T., et al. Simultaneous study of matrix metalloproteinases, proinflammatory cytokines, and soluble cytokine receptors in the tears of noninfectious corneal ulcer patients. Graefes Arch Clin Exp Ophthalmol Pubslished online July 2014. DOI 10.1007/s00417-014-2708-1
    Species: Human

  22. Thielitz A, Vetter R, Schultze B, Wrenger S, Simeoni L,et al.Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts. J Investig Dermatol. 2008;128:855?866
    Species: Human
    Sample Type: Conditioned Media

  23. Harper JI, Godwin H, Green A, Wilkes LE, Holden NJ, et al. A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis. Br J Dermatol. 2010 Feb 1;162(2):397?403.
    Species: Human

  24. Steed D, Trumpower C, Duffy D, Smith C, Marshall V, et al. Amnion-derived Cellular Cytokine Solution A Physiological Combination of Cytokines for Wound Healing. Eplasty. 2008;8:e18.
    Species: Human
    Sample Type: Conditioned Media