Mouse Anti-CaMKIV

Mouse Anti-CaMKIV Antibody, 100 µl
CODE:  102-26488

Product Specifications

Size:
100 µl

Protein Information

Accession Number:
  • Q16566
Gene ID:
  • 814
Gene Symbols:
  • CAMK4
Protein Name & Synonyms:
Brain Ca(2 ) calmodulin dependent protein kinase type 4;Brain Ca(2 ) calmodulin dependent protein kinase type IV;Brain Ca -calmodulin dependent protein kinase type IV;Calcium / calmodulin dependent protein kinase type 4 catalytic chain;Calcium / calmodulin dependent protein kinase type IV catalytic cha

Antibody Specifications

Applications:
WB
Host Species:
Mouse
Species Reactivity:
H
Clonality:
Monoclonal

Introduction

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Other Information

Antigen Type
Recombinant Protein

Images

WB (1:1000)

Western blot detection of CaMKIV in Romas and Jurkat cell lysates using CaMKIV mouse mAb (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa.

WB

Storage/Stability

2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.