Protein Name & Synonyms:
IgG concentration 0.1mg/ml
Dog, Human, Mink
This product recognizes canine CD107b, otherwise known as LAMP-2, a 95kDa heavily-glycosylated type I integral lysosomal glycoprotein, shown to share high N-terminal amino acid sequence homology with human, mouse and rat CD107b.
Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion.
Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumour cells and their metastatic potential.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Phosphate buffered saline
MDCK (Madin-Darby Canine Kidney) cells.
|0.09%||Sodium Azide (NaN3)|
|1%||Bovine Serum Albumin|
Spleen cells from immunised Balb/c mice were fused with cells of the NS1 myeloma cell line.