Protein Name & Synonyms:
Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blotting
IgG concentration 1.0mg/ml
Dog, Human, Mink
This product recognizes canine CD107b, otherwise known as LAMP-2, a 95kDa heavily-glycosylated type I integral lysosomal glycoprotein, shown to share high N-terminal amino acid sequence homology with human, mouse and rat CD107b.
Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion.
Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumour cells and their metastatic potential.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
MDCK (Madin-Darby Canine Kidney) cells.
Spleen cells from immunised Balb/c mice were fused with cells of the NS1 myeloma cell line.