Mouse Anti-Chicken CD45 [+RPE]

Mouse Anti-Chicken CD45 [+RPE]

DS-MB-02692
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Antigen Information

Protein Name & Synonyms:
CD45
Target Species:
  • Chicken

Antibody Specifications

Applications:
Flow Cytometry
Reconstitution:
Reconstitute with 1.0 ml distilled water
Species Reactivity:
Chicken

Specificity

This product recognizes chicken CD45 (leucocyte common antigen), a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of hematopoietic origin. Variation in the expression of a particular CD45 isoform, is regulated during the hematopoietic development of the different cell lineages.

CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, acts in balance with protein tyrosine kinases, causing the dephosphorylation of negative regulatory tyrosine sites. Studies have indicated that dephosphorylation by CD45, is required for the activation of the src-family kinases p56lck and p59fyn.

Investigations into the properties of CD45 in chicken models are limited, but there is evidence of the existence of an additional cysteine residue near the transmembrane region. The overall domain structure between mammalian and chicken CD45 appears to be conserved, but the sequence homology between the extracellular regions is very low.

Storage/Stability

Prior to reconstitution store at +4 °C.
After reconstitution store at +4 °C.
DO NOT FREEZE. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 1.0 ml distilled water

Preparation

Immunogen:
COS cells transfected with CD45 gene.
Preservative:
0.09%Sodium Azide
1%Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.