This product detects bands of approximately 32kDa and 37kDa in cell lysates.
This product recognizes human B-cell lymphoma/leukaemia 10 (Bcl-10), a 31kD CARD (caspase recruitment domain) containing molecule that is involved in the regulation of apoptosis. Bcl-10 was originally identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. The Bcl-10 molecule is predominantly located in the cytoplasm but expression has also been reported in the nucleus of some lymphomas.
Recent reports suggest that Bcl-10 is essential for nuclear factor (NF)-kappaB activation after lymphocyte receptor antigen stimulation and for the development of mature B-cells.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.