Mouse Anti-Human C1q

Mouse Anti-Human C1q

$558.00
DS-MB-02778
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Antigen Information

Protein Name & Synonyms:
C1q
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, ELISA (dilution: 1:500, 1:1000), Flow Cytometry, Immunofluorescence
Concentration:
1.0 mg/ml
Species Reactivity:
Human
Immunohistology:
Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).

Specificity

This product recognizes human complement component 1, q subcomponent (C1q), a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Globular head domain of C1q, purified from human plasma.
Preservative:
0.09% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.