Mouse Anti-Human CD147, azide-free

Mouse Anti-Human CD147, azide-free (0.1 mg)

DS-MB-02828
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Antigen Information

Protein Name & Synonyms:
CD147
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry, Functional Assays, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Human

This product detects a band of approximately 45-60kDa in 293 human fibroblastoid cell lysates under non-reducing conditions.

Specificity

This product specifically recognizes the Ig domain D2 of human CD147, otherwise known as neurothelin, a type I transmembrane glycoprotein and member of the immunoglobulin gene superfamily, broadly expressed on peripheral blood cells, endothelial cells, and increased on T cells following activation. CD147 is also strongly expressed on small lung cancer cells and hepatocellular carcinoma.

Biological properties of CD147 include the regulation of T cells, integrin functions and cell adhesion, the stimulation of metalloproteinase (MMP) production by fibroblasts, the promotion of astrocyte outgrowths, and roles in tumour progression, neuronal system function and reproduction.

This product inhibits anti-CD3-induced T cell activation, dependent upon antibody concentration(1 ).

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Azide Free

Preparation

Immunogen:
CD147Rg, consisting of the CDNA coding for the hinge region, CH2-and CH3 domain of human IgG1.
Preservative:
None present
This product
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.