Mouse Anti-Human CD221, low endotoxin

Mouse Anti-Human CD221, low endotoxin (0.5 mg)

DS-MB-00508
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Antigen Information

Protein Name & Synonyms:
CD221
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry, Functional Assays, Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human

Specificity

This product recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. This antibody recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting, see Li, S.L. et al. for details.

CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.

The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. This product is reported to partically block binding of IGF-I and IGF-II to CD221, see Li, S.L. et al for details.

Storage/Stability

Store at -20 °C only.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Quality Control (Contaminants):
<0.01 EU/ug
Format Type:
Low Endotoxin

Preparation

Preservative:
None present
This product
Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.