Protein Name & Synonyms:
Flow Cytometry, Functional Assays, Immunoprecipitation
IgG concentration 1.0 mg/ml
This product recognizes human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.
This product is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells, see Kojima, H. et al. for details.
Store at -20 °C only.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Quality Control (Contaminants):
Human cytotoxic T lymphocyte clone
Spleen cells from immunised BALB/c mouse were fused with cells of the Sp2/0 myeloma cell line.