Mouse Anti-Human CD243 [+RPE]

Mouse Anti-Human CD243 [+RPE] (100 TESTS)

$511.00
DS-MB-02938
+

Antigen Information

Protein Name & Synonyms:
CD243
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry
Reconstitution:
Reconstitute with 1.0ml distilled water
Species Reactivity:
Human, Primate

Specificity

This product specifically recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, which acts as an active efflux pump for a diverse range of lipophillic compounds.

CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. CD243 mediates resistance to many chemotherapeutic agents used for tumour suppression and is therefore of special interest to oncologists. This product is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs.

Storage/Stability

Prior to reconstitution store at +4 °C.
After reconstitution store at +4 °C.
DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 1.0ml distilled water

Preparation

Immunogen:
Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.
Preservative:
0.09%Sodium Azide (NaN3)
1%Bovine Serum Albumin
5%Sucrose

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.