Protein Name & Synonyms:
Flow Cytometry, Immunoprecipitation
IgG concentration 1.0 mg/ml
This product is specific for human death receptor 4 (DR4), also known as CD261 or TRAIL- R1. DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines.
DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis.
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Fusion protein containing the extracellular region of CD261 (DR4).
Spleen cells from immunised F1 hybrid mice were fused with cells of the SP2/0-Ag14 myeloma cell line.