Mouse Anti-Human CD272

Mouse Anti-Human CD272 (0.1 mg)

DS-MB-02955
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Antigen Information

Protein Name & Synonyms:
CD272
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Flow Cytometry
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Human

Specificity

This product detects human CD272, also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type I transmembrane glycoprotein which is structurally and functionally related to cytotoxic T lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1). CD272 is a T-cell inhibitory receptor that regulates T cell activation through its interaction with herpes virus entry mediator (HVEM), a co-stimulator receptor of the TNFR family.

CD272 may negatively regulate T-cell dependent autoimmune reaction, and polymorphisms in its gene have been associated with Rheumatoid Arthritis.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
BTLA - transfected L cells.
Preservative:
0.09%Sodium Azide (NaN3)
This product
Spleen cells from immunised C3H/HeN mice were fused with cells of the P3U1 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.