Protein Name & Synonyms:
Immunohistology - Frozen, Flow Cytometry
IgG concentration 1.0mg/ml
This product detects CD275, also known as ICOS ligand (inducible T cell co-stimulator ligand). CD275 is a member of the B7 family, and interaction with its receptor CD278 (ICOS) plays an important role in T cell co-stimulation and inflammatory immune reactions.
CD275 is expressed on activated B-cells, monocytes and dendritic cells and is also induced on non-lymphoid tissue cells such as endothelial cells, epithelial cells and muscle cells. CD275 has an important physiological role in the reactivation of effector/memory T cells on the endothelium, thus controlling entry of immune cells into inflamed tissue.
The CD278-CD275 pathway is thought to be critical in the immune response to transplants, allergies and autoimmune diseases.
This antibody is reported to partially block the interaction between CD275 and CD278.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
CD275 - L cells
Spleen cells from immunised BALB/c mice were fused with cells of the P3U1 myeloma cell line.